化学
立体化学
植物化学
内酯
戒指(化学)
二维核磁共振波谱
萜烯
萜类
二萜
有机化学
生物化学
作者
En Cheng,Jun Chen,Yixiao Li,Wei-Jin Zhang,Na Huang,Zhimin Wang,Liping Dai,Erqi Xu
标识
DOI:10.1016/j.tetlet.2022.154119
摘要
Phytochemical investigation of Isodon henryi led to the isolation of two new diterpenoids, isohenolides A-B (1–2), one new natural diterpenoid (3) and thirteen known ones (4–16). These diterpenoids showed various ent-kaurane skeletons, in which isohenolide A (1) was a rare 6,8‑cyclo ent-kaurane containing an unprecedented 11,15-lactone group, and possessed a 6/5/6/6/6/6 ring system. Their structures were confirmed by comprehensive UV, IR, HRESIMS, NMR analyses and ECD calculations. Most compounds were also screened for anti-inflammatory actions on LPS-induced RAW 264.7 cells, and compounds 8 and 16 exhibited stronger NO inhibition.
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