基因沉默
生物
癌症研究
RNA干扰
免疫系统
癌症免疫疗法
免疫疗法
核糖核酸
信号转导
先天免疫系统
小发夹RNA
小干扰RNA
免疫学
细胞生物学
基因
遗传学
作者
Xue‐Bin Ran,Ling‐Wen Ding,Qiao-Yang Sun,Henry Yang,Jonathan W. Said,Zhentang Lao,Vikas Madan,Pushkar Dakle,Jin-Fen Xiao,Xin-Yi Loh,Ying Li,Liang Xu,Xiaoqiang Xiang,Lingzhi Wang,Boon Cher Goh,De‐Chen Lin,Wee Joo Chng,Soo‐Yong Tan,Sudhakar Jha,H. Phillip Koeffler
出处
期刊：Cancer Research
[American Association for Cancer Research]
日期：2023-01-13
卷期号：83 (6): 922-938
被引量：21
标识
DOI：10.1158/0008-5472.can-21-3052
摘要
Targeting XRN1 activates an intracellular innate immune response mediated by RNA-sensing signaling and potentiates cancer immunotherapy efficacy, suggesting inhibition of RNA decay machinery as a novel strategy for cancer treatment.
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