癌症免疫疗法
免疫疗法
免疫系统
佐剂
肿瘤微环境
免疫增强剂
自噬
癌症研究
免疫原性细胞死亡
癌细胞
抗原
化学
癌症
生物
免疫学
生物化学
细胞凋亡
遗传学
作者
Lingxiao Zhang,Yingbo Jia,Jin-ju Yang,Lun Zhang,Shengjie Hou,Xiaofeng Niu,Jie Zhu,Yaru Huang,Xiaoying Sun,Zhi Ping Xu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-26
卷期号:16 (8): 12036-12048
被引量:37
标识
DOI:10.1021/acsnano.2c02183
摘要
Cancer immunotherapy efficacy is largely limited by the suppressive tumor immune microenvironment (TIME) where antitumor immune cells are inhibited and tumor antigens continue to mutate or be lost. To remodel the TIME, we here applied weakly alkaline layered double hydroxide nanoparticles (LDH NPs) to neutralize the excess acid and block autophagy of tumor cells for neoadjuvant cancer immunotherapy. Peritumoral injection of LDH NPs provided a long-term and efficient acid-neutralization in the TIME, blocked the lysosome-mediated autophagy pathway in tumor cells, and increased the levels of antitumor tumor-associated macrophages and T cells. These LDH NPs captured tumor antigens released in the tumor tissues and effectively inhibited the growth of both melanoma and colon tumors in vivo. These findings indicate that LDH NPs, as an immunomodulator and adjuvant, successfully "awaken" and promote the host innate and adaptive immune systems, showing promising potential for solid tumor immunotherapy.
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