Guided Discovery of Antidiabetic Sesquiterpenoids From Lindera Aggregate by Activity Labeled Molecular Networking

As results indicated, all the eight compounds showed significant antidiabetic effects, which were consistent with the obtained activity annotations by ALMN. The mechanism of the antidiabetic activity for 1-8 were further delved via Akt/GSK3β signal pathway, which can be observed as potential agents against the insulin resistance for the insulin resistance Type II diabetes.