免疫监视
结直肠癌
转移
癌症
医学
酪氨酸激酶2
癌症研究
肿瘤科
内科学
疾病
作者
Bernadette Mödl,Daniela Zwolanek,Katharina Schwertner,Dana Krauß,Stefan Moritsch,Irene Scharf,A. Ebner,Verónica Moreno‐Viedma,Cristiano De Sá Fernandes,Philipp Novoszel,Martin Holcmann,Martina Hammer,Nunzia Matrone,Michaela Schlederer,Birgit Strobl,Emilio Casanova,Caroline Lassnig,Dietmar Herndler‐Brandstetter,Lukas Kenner,Mathias Müller
出处
期刊：Cancer Research
[American Association for Cancer Research]
日期：2025-09-24
卷期号：86 (1): 80-98
标识
DOI：10.1158/0008-5472.can-24-4224
摘要
TYK2 restricts the metastasis of colorectal tumors to the liver by supporting dendritic cell-dependent induction of antitumor CD8+ T cells, which could impact the use of TYK2 inhibitors in patients.
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