In this study, natural ventilation and energy performance of multi-stories type double skin facade(DSF) was evaluated according to its opening design. The objective of this study is to suggest design method for reducing cooling load of office building with DSF. study is to suggest design method for reducing cooling load of office building with DSF. Energyplus simulation with airflow network is conducted to analyze on thermal, airflow condition and indoor cooling load of each alternative. Using the simulation baseline of the previous study,natural ventilation and indoor cooling energy performance is analyzed by air temperature and total pressure according to opening and wind direction at upper part of DSF. As results of this study, ALT2 applied top side opening reacts to outdoor wind direction flexibly, and shows excellent performance in terms of the natural ventilation(49.3% improvement compared to the Baseline) and the indoor cooling load(5.9% improvement compared to the Baseline).