生物合成
化学
计算生物学
生物化学
组合化学
生物
酶
作者
Hao Fan,Xia Wei,Mei-Xia Si-Tu,Yan-Hu Lei,Feng-Guo Zhou,Cui‐Xian Zhang
标识
DOI:10.1002/cbdv.202200208
摘要
γ-Aromatic butenolides (γ-AB) are an important type of structures found in many bioactive microbial secondary metabolites (SMs). γ-AB refer to a group of natural products (NPs) containing five-membered (unsaturated) lactones with 3-phenyl and 4-benzyl substituents. Their wide-range biological activities have inspired pharmaceutical chemists to explore its biosynthesis mechanisms and design strategies to construct the γ-AB skeleton. Recently, there are a great deal of interesting research progress on the structures, biological activities and biosynthesis of γ-AB. This review will focus on these aspects and summarize the important achievements of γ-AB from 1975 to 2021.
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