Nanozymes of Ni 0.5 Fe 0.5 S 2 Mediated Synergetic Antitumor Treatment

How to establish a multi-modality oncotherapy method on the basis of single matter mediated utilization of tumor endogenous substances is very promising for the efficient antitumor treatment. In this work, we have designed a metallic Ni 0.5 Fe 0.5 S 2 nanosphere for the synergetic chemodynamic/photodynamic/photothermal antitumor treatments. Under NIR excitation, a remarkable photothermal effect could be generated by Ni 0.5 Fe 0.5 S 2 for realizing the photothermal therapy. Meanwhile, Ni 0.5 Fe 0.5 S 2 could also trigger formation of reactive oxygen species (ROS) via transformation of tumor-site oxygen for the further photodynamic therapy. Furthermore, peroxidase-like property of Ni 0.5 Fe 0.5 S 2 favors the catalysis of endogenous H 2 O 2 into hydroxyl radical to achieve a chemodynamic therapy. As a result, the on-site tumor hyperthermia, tumor-site oxygen and H 2 O 2 conversion are worked for the antitumor action. On the merits of above synergistic effect, a better antitumor outcome was confirmed as compared with any single antitumor action, and complete removal of solid tumor under a relative lower temperature has been accomplished.