精索静脉曲张
氧化应激
不育
男性不育
背景(考古学)
活性氧
脂质过氧化
病理生理学
男科
精子发生
生物
生育率
医学
生物信息学
生理学
内分泌学
细胞生物学
遗传学
人口
环境卫生
怀孕
古生物学
作者
Kaixian Wang,Yuanyuan Gao,Chen Wang,Meng Liang,Yaping Liao,Ke Hu
标识
DOI:10.3389/fgene.2022.850114
摘要
According to the official statistics of the World Health Organization, at least 48 million couples and 186 million people suffer from infertility. Varicocele has been recognized as the leading cause of male infertility and can affect spermatogenesis and cause testicular and epididymal disorders through multiple diverse pathophysiological processes. Reactive oxygen species (ROS) produced by oxidative stress have been reconciled as an important pathogenic factor throughout the course of varicocele. Testis respond to heat stress, hypoxia, and inflammation at the cost of producing excessive ROS. High levels of ROS can lead to infertility not only through lipid peroxidation or DNA damage, but also by inactivating enzymes and proteins in spermatogenesis. This review studies the oxidative stress and its role in the pathophysiology and molecular biology of varicocele in the context of a decline in fertility.
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