非酒精性脂肪肝
肠道菌群
毛螺菌科
脂肪肝
内科学
内分泌学
肝损伤
肝病
生物
医学
生物化学
疾病
16S核糖体RNA
基因
厚壁菌
作者
Kunli Wang,Bei Li,Rao Fu,Zefang Jiang,Xin Wen,Yingdong Ni
标识
DOI:10.1111/1750-3841.16076
摘要
Abstract The present study aimed to examine the protective effect of Bentong ginger oleoresin (BGO) on the occurrence of nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. In the present study, 14‐week BGO treatment reduced the high‐fat diet (HFD)‐induced obesity. The serum total cholesterol (TC) was reduced from 4.76 ± 0.30 to 3.542 ± 0.49 mmol/L and fatty liver score decreased to the normal level (1.6 ± 0.55). BGO had antihypercholesterolemia activity, alleviated abnormal lipid metabolism, and improved liver fat accumulation. In addition, liver inflammatory cytokine tests and Western blotting analysis indicated that BGO might play an anti‐inflammatory role by mediating the NF‐κB signaling pathway. Moreover, BGO regulated the gut microbiota in NAFLD mice and finally mediated their benefits for the host, which might be associated with reduced abundance of Lachnospiraceae_NK4A136_group and Fournierella . BGO showed effective liver protection and regulation of gut microbiota for the HFD‐induced NAFLD in obese mice. As a result, BGO may serve as an effective dietary supplement for the improvement of NAFLD‐related metabolic diseases. Practical Application This study provides a new way to improve the added value of Bentong ginger. It also provides certain experimental data on BGO as a kind of the functional food ingredient. The current work also provides new ideas for the improvement and treatment of NAFLD.
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