化学
检出限
催化作用
尿酸
电化学
生物分子
多巴胺
酶
线性范围
电化学气体传感器
生物传感器
无机化学
组合化学
色谱法
生物化学
电极
物理化学
神经科学
生物
作者
Fuad Abduro Bushira,Shimeles Addisu Kitte,Haijuan Li,Lirong Zheng,Ping Wang,Yongdong Jin
标识
DOI:10.1016/j.jelechem.2021.115956
摘要
Simultaneous highly sensitive and accurate detection of dopamine (DA) and uric acid (UA) is of great importance since they are important biomolecules that are commonly coexisted in the human body and play a crucial role in numerous physiological and pathological features. In this work, Fe-N5 single atom catalyst (SAC) supported on graphene was firstly employed for simultaneous electrochemical detection DA and UA. Owing to its unique electronic structure and abundant active sites, under optimal conditions, the enzyme-like Fe-N5 SAC constructed electrochemical (bio)sensor exhibits excellent linear characteristic responses in the range of 0.005–500 and 0.01–480 µM, as well as the low limit of detection of 0.007 and 0.027 nM for DA and UA, respectively. More critically, the developed electrochemical system shows promising merits of exceptional stability, good repeatability, and, consequently, it was successfully applied for simultaneous sensitive detection of DA and UA in human serum samples.
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