Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

(Immunity 27, 670–684; October 2007) In the version of this article published online on October 18, 2007, data in the first column of Table S2 were stretched in the process of file conversion, and data from the second, third, and fourth columns of the same table were missing. The complete version of the table now appears online. Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral InfectionWherry et al.ImmunityOctober 26, 2007In BriefChronic viral infections often result in T cell exhaustion. To determine the molecular signature of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells from chronic infection to functional LCMV-specific effector and memory CD8+ T cells generated after acute infection. These data showed that exhausted CD8+ T cells: (1) overexpressed several inhibitory receptors, including PD-1, (2) had major changes in T cell receptor and cytokine signaling pathways, (3) displayed altered expression of genes involved in chemotaxis, adhesion, and migration, (4) expressed a distinct set of transcription factors, and (5) had profound metabolic and bioenergetic deficiencies. Full-Text PDF Open Archive