Objective: The purpose of this study was to investigate the effect of an 8-week ProBody massage program on body alignment and plantar pressure balance in middle-aged men with musculoskeletal diseases. Method: The subjects of this study were 20 middle-aged men with musculoskeletal diseases in B Metropolitan City who participated in an 8-week ProBody massage program conducted twice a week. Physical characteristics (height, weight, and body mass index), body alignment, and plantar pressure were assessed before and after the experiment. Results: The 20 middle-aged men with musculoskeletal diseases who underwent the ProBody massage program showed positive changes in physiological characteristics, body alignment, and plantar pressure balance. Conclusion: Consequently, the 8-week ProBody massage program was suggested to be effective for improving and preventing postural imbalance in middle-aged men with musculoskeletal diseases. The ProBody massage program could also be utilized to improve the body alignment and plantar pressure balance in middle-aged women with musculoskeletal diseases.