神经发生
神经保护
神经科学
血管内皮生长因子
环境富集
血管生成
神经可塑性
海马结构
心理学
医学
血管内皮生长因子受体
内科学
作者
Valentina Echeverria,George E. Barreto,Marco Avila-Rodriguezc,Vadim V. Tarasov,Gjumrakch Aliev
标识
DOI:10.2174/1567205014666170329113007
摘要
The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, two non-pharmacological interventions that are beneficial decreasing the progression of Alzheimer disease (AD) and depressive-like behavior, enhance hippocampal VEGF expression and neurogenesis. Furthermore, the stimulation of VEGF expression promotes neurotransmission and synaptic plasticity processes such as neurogenesis. It is thought that these VEGF actions in the brain, may underly its beneficial therapeutic effects against psychiatric and other neurological conditions.In this review, evidence linking VEGF deficit with the development of AD as well as the potential role of VEGF signaling as a therapeutic target for cotinine and other interventions in neurodegenerative conditions are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI