医学
抗生素
抗菌剂
重症监护医学
黄疸
混淆
疾病
肝病
广谱
肝功能不全
传染病(医学专业)
药品
梅德林
内科学
药物治疗
药理学
微生物学
化学
生物
组合化学
作者
Jonathan G. Stine,James H. Lewis
标识
DOI:10.1016/j.cld.2013.07.008
摘要
Collectively, the various classes of antibiotics are a leading cause of drug-induced liver injury (DILI). However, acute antibiotic-associated DILI can be difficult to diagnose, as the course of therapy is usually brief, and other confounding factors are often present. In addition to the broad clinicopathologic spectrum of hepatotoxicity associated with the antimicrobials, the underlying infectious disease being treated may itself be associated with hepatic dysfunction and jaundice. This review provides summarized information on several classes of antimicrobial agents, highlighting new agents causing DILI and updating information on older agents.
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