Anesthesia and Postoperative Cognitive Dysfunction (POCD)

POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.