相扑蛋白
生物钟
昼夜节律
生物
细胞生物学
遗传学
转录因子
时钟
神经科学
泛素
基因
作者
Luca Cardone,Jun Hirayama,Francesca Giordano,Teruya Tamaru,Jorma J. Palvimo,Paolo Sassone‐Corsi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-08-26
卷期号:309 (5739): 1390-1394
被引量:277
标识
DOI:10.1126/science.1110689
摘要
The molecular machinery that governs circadian rhythmicity is based on clock proteins organized in regulatory feedback loops. Although posttranslational modification of clock proteins is likely to finely control their circadian functions, only limited information is available to date. Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine residue (Lys259) in vivo. BMAL1 shows a circadian pattern of SUMOylation that parallels its activation in the mouse liver. SUMOylation of BMAL1 requires and is induced by CLOCK, the heterodimerization partner of BMAL1. Ectopic expression of a SUMO-deficient BMAL1 demonstrates that SUMOylation plays an important role in BMAL1 circadian expression and clock rhythmicity. This reveals an additional level of regulation within the core mechanism of the circadian clock.
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