5-HT7受体
受体
5-HT5A受体
5-羟色胺受体
生物
酶联受体
代谢受体
海马结构
神经科学
雌激素相关受体α
放射性配体
腺苷酸环化酶
白细胞介素-21受体
雌激素相关受体γ
内分泌学
内科学
雌激素受体
血清素
医学
谷氨酸受体
生物化学
遗传学
癌症
乳腺癌
作者
Peter B. Hedlund,J. Gregor Sutcliffe
标识
DOI:10.1016/j.tips.2004.07.002
摘要
The 5-HT7 receptor was among a group of 5-HT receptors that were discovered using targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G-protein-coupled receptor that is positively linked to adenylyl cyclase. The distributions of 5-HT7 receptor mRNA, immunolabeling and radioligand binding exhibit strong similarities, with the highest receptor densities present in the thalamus and hypothalamus and significant densities present in the hippocampus and cortex. The recent availability of selective antagonists and knockout mice strains has dramatically increased our knowledge about this receptor. Together with unselective agonists, these new tools have helped to reveal the 5-HT7 receptor distribution in more detail. Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established. Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression.
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