间充质干细胞
Wnt信号通路
细胞生物学
生物
转录因子
细胞分化
干细胞
成纤维细胞生长因子
信号转导
骨形态发生蛋白
遗传学
基因
受体
作者
Birru Bhaskar,Naveen Kumar Mekala,Rama Raju Baadhe,Parcha Sreenivasa Rao
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2014-08-12
卷期号:9 (6): 508-512
被引量:40
标识
DOI:10.2174/1574888x09666140812112002
摘要
Mesenchymal Stem Cells (MSCs) are self-renewing cells with ability to differentiate into organized, functional network of cells. In recent past research in developing clinical applications for MSCs has increased significantly. MSCs exhibit multi potential proliferation, and are capable of differentiating into cartilage, bone, neuronal cells and adipocytes, etc. Signaling pathways, transcription factors and growth factors modulate the differentiation of MSCs into different cell lineages. Besides, physical factors may regulate the molecular differentiation of stem cells. The main theme of this paper is to review the signaling pathways related to bone morphogenetic proteins (BMPs), epidermal growth factors (EGF), transforming growth factors (TGF), wingless type MMTV integration site (wnt) proteins, fibroblastic growth factor (FGF), and transcriptional regulating factors significance in the MSCs differentiation. Keywords: Differentiation, growth factors, mesenchymal stem cells (MSCs), signaling pathways.
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