Capillary electrophoresis enantioseparation of drugs using β-cyclodextrin polymer: Intramolecular synergistic effect

Enantiomers of eight basic compounds of pharmaceutical interest were studied by capillary electrophoresis (CE) using a soluble cyclodextrin (CD) polymer and native CD as chiral selectors. The effects of the polymer concentration and the pH of the buffer solution on resolution were examined. It was found that the β-CD polymer shows higher stereoselectivity than its parent cyclodextrin. Such improvement is due to the structural difference between β-CD and β-CD polymer. These results suggested the existence of an intramolecular synergistic effect in CE.