止血器
止血
材料科学
组织粘连
右旋糖酐
凝结
生物医学工程
伤口愈合
止血剂
溶血
粘附
海绵
外科
化学
医学
色谱法
复合材料
生物
免疫学
精神科
植物
作者
Chunyu Liu,Xia Liu,Chenyu Liu,Ning Wang,Hailiang Chen,Weihe Yao,Guozhen Sun,Qiling Song,Weihong Qiao
出处
期刊:Biomaterials
[Elsevier]
日期:2019-06-01
卷期号:205: 23-37
被引量:161
标识
DOI:10.1016/j.biomaterials.2019.03.016
摘要
Uncontrolled hemorrhage is closely related to the high risk of death. However, local hemostats still have various defects and side effects. Herein, an aldehyde dextran (PDA) sponge with proper absorption and adhesion properties is developed for hemorrhage control. PDA sponge with pore size of ∼30–50 μm fabricated by lyophilization not only absorbs blood quickly (47.7 g/g), but also possesses strong tissue adhesion (∼100 kPa). PDA sponge with low cytotoxicity and hemolysis achieves effective hemostasis and remarkable blood loss reduction in the ear vein, femoral artery and liver injuries of rabbit models. Furthermore, the exploration of hemostatic mechanisms related to tissue, blood, plasma, cells and coagulation system indicates that PDA sponge can significantly accelerate coagulation by rapid wound block, fast cells aggregation and initiation, and high coagulation factors concentration, instead of by the coagulation cascade activation. Importantly, this hemostat exhibits excellent biodegradability and nearly no skin irritation. Overall, the biodegradable and tissue adhesive PDA sponge will be a promising quick-hemostatic dressing for uncontrollable hemorrhage.
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