The authors' 10-year experience with the treatment of 134 patients suffering from ulcerative colitis is presented. The standard with sulfasalazine proved successful in mild forms of the disease, yet preparations containing only 5-aminosalicylic acid had to be administered to patients with intermediate and serious forms of the disease. The authors recommend to individualize treatment with corticoids and antibiotics and to reserve this approach for severe conditions. The use of supplementary therapeutic procedures, particularly administration of drugs affecting the immune system, is still a rather controversial issue. (Tab. 3, Ref. 24).