In addition to the regulation of the nerve system,function of digestive organs is also regulated by gastrointestinal hormones.The regulation of gastrointestinal hormone is taken as an important supplement to the regulation of the nerve system and even plays a leading role in the regulation of some digestive organ activities.So far,more than sixty kinds of gastrointestinal hormones have been discovered.and the research of them has also rapidly developed.Extensive experimental results demonstrate that parasecretion of some gastrointestinal hormones has a close relationship with the pathophysiological basis of the gastrointestinal diseases.Here is to make a review of the effect of several major gastrointestinal hormones on the gastrointestinal tract,and their relationship with the common gastrointestinal diseases.