Study of the clinical efficacy of topiramate in treatment of epilepsy

Objective:To study the efficacy of low dose topiramate(200mg) in treatment of epilepsy.Methods:73 patients with epilepsy were divided to receive once daily single 25 mg topiramate or in combination with other antiepileptic( n =33),or to receive carbamazapine( n =40) as control.Results:The effective rate of the active group(93.9%) was significantly higher than that of the control group(77.5%, P 0.05) and the distinct effective rate of single topiramate was signicantly better than that of combined topiramate therapy ( P 0.05).Conclusion:The efficacy of topiramate in treatment of epilepsy is better than that of other antiepileptics,and the efficacy of single topiramate therapy is better than that of the combined topiramate therapy. [