As a new fluorescent dye,dipyrromethene boron difuoride(BODIPY)was investigated intensively over the last two decades due to their excellent photophysical properties.Functionalization of the BODIPY core would form a series of derivatives,which can be used in the fields of environmental monitoring and biological sciences,etc.Functionalization method of BODIPY dyes and their used as fluorescence probes,fluorescence labels and photosensitizer in recent years were reviewed.