Abstract: Pragmatic strategies to improve antibiotic prescribing will be discussed in this session. Although a whole healthcare economy approach to antibiotic stewardship will be advocated, the particular focus will be within acute health care. Implementation and adoption will be considered along with improvement methods in stewardship. Supporting organisational models will also be reviewed and practical examples and case studiesdescribed. The real and potential challenges faced in delivering effective antibiotic stewardship and sustaining improvement will be discussed.