[The effect of TNF-alpha & IL-8 in the pathogenesis of allergic rhinitis].

OBJECTIVE: To survey the effects of TNF-alpha and IL-8 in the pathogenesis of allergic rhinitis. METHOD: The serum levels of TNF-alpha and IL-8 in 102 cases of seasonal or non-seasonal allergic rhinitis were detected pre and post specific immunotherapy (SIT), and the results were statistically analyzed. RESULT: The levels of TNF-alpha and IL-8 in experiment group were significant higher than that in the health control. And the levels of TNF-alpha and IL-8 significantly decreased post SIT in the experiment group. CONCLUSION: TNF-alpha and IL-8 play important roles in the pathogenesis of allergic rhinitis.