Determination of hydrogen peroxide in polysorbate 80 by indirect catalatic iodimetry method

Objective:Determine the hydrogen peroxide residue in polysorbate 80 by the Indirect Iodimetry Method using catalase.Method:The superoxide values in polysorbate 80 will decreased after decomposition of hydrogen peroxide catalyzed by catalase.The content of hydrogen peroxide would been calculated from the decreasing value.Results:18 batches polysorbate 80 from seven producers were analysed,the maximum hydrogen peroxide content was 185.3 μg·g-1.Conclusion:The hydrogen peroxide residue in polysorbate 80 is very dangerous for the injection,the method mentioned in this text is convenient and efficient to determine the hydrogen peroxide residue in polysorbate 80.