Asymmetric Synthesis of Axially Chiral Natural Products

Axial chirality unit is engrafted in naturally occurring compounds that could exhibit wide-range biological activities. They are isolated as single atropisomers or as mixtures because of the dynamic nature of atropisomerism. Enclosed in this chapter are focused discussions on key steps involved to form the chiral axis of interest in selected natural products. The plausible coexistence of central chirality and inherent skeletal diversity of atropisomers (as heterobiaryl or non-biaryl-type structures containing rotationally restricted C–C, C–N, or N–N linkages) have called for innovative synthetic strategies, which include diastereoselective coupling, catalytic atroposelective coupling, asymmetric transformation of biaryls, atroposelective aromatization, and diastereoselective macrocyclization.