除氧
沃尔夫重排
化学
施陶丁格反应
光催化
光催化
芳基
催化作用
蒂奥-
组合化学
光化学
有机化学
烯酮
烷基
作者
Hui Yang,Haijun Li,Guo Wei,Zhiyong Jiang
标识
DOI:10.1002/anie.202107080
摘要
A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.
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