光热治疗
血红素
阿霉素
材料科学
脚手架
生物医学工程
骨肉瘤
化学
体内
3d打印
纳米技术
化疗
癌症研究
医学
外科
酶
生物技术
血红素
生物
生物化学
作者
Wentao Dang,Yuanyuan Jin,Ke Yi,Enguo Ju,Chenya Zhuo,Hongyan Wei,Xingqiao Wen,Yu Wang,Mingqiang Li,Yu Tao
标识
DOI:10.1016/j.cej.2021.129919
摘要
Simultaneously eliminating tumor cells and filling the bone defects after tumor resection is still highly challenging for clinical bone tumor treatment. Three-dimensional (3D) printing technology, which provides scaffolds with patient-specific accurate geometry and desirable feature, has gained great attention for supplying a promising candidate for therapy of bone tumors. In this work, we constructed multifunctional scaffolds by coating hemin and doxorubicin (DOX) on the strut surface of 3D-printed bioactive glass ceramics (BGC-HM-DOX). Owing to the surficial hemin particles, BGC-HM-DOX scaffolds showed excellent photothermal response under near-infrared laser irradiation. Besides, BGC-HM-DOX scaffolds could effectively kill osteosarcoma cells in vitro and suppress tumor growth in vivo via the combination of photothermal therapy and chemotherapy. Therefore, this scaffold may provide a high clinical potential for precision medicine in tumor-induced bone defect management.
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