化学
细胞分化
下调和上调
癌症研究
调节性T细胞
T细胞
细胞生长
作者
Xu Liu,Na Tian,Qianru Huang,Xu Zhan,Hao Cheng,Xinnan Liu,Dan Li,Rui Liang,Bin Li,Xueyu Dai
出处
期刊:FEBS Letters
[Wiley]
日期:2021-07-01
卷期号:595 (14): 1962-1974
标识
DOI:10.1002/1873-3468.14142
摘要
Regulatory T cells (Tregs) are indispensable for the maintenance of immunological self-tolerance and homeostasis. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is required for optimal Treg induction. Here, we reveal that human-induced Tregs (iTregs) lacking hnRNPA1 show reduced expression of the transcription factor FOXP3, increased ubiquitination level of FOXP3, and impaired suppressive abilities. Human naive CD4 T cells with hnRNPA1 knockdown show a decreased Treg differentiation ratio. hnRNPA1 could interact with FOXP3 as well as with the E3 ligase Stub1. The phosphorylation at hnRNPA1 S199 could increase both interactions. The overexpression of FOXP3 in Tregs containing shhnRNPA1 could not recover the phenotype caused by hnRNPA1 knockdown. Therefore, there might be multiple essential pathways regulated by hnRNPA1 in Tregs. In conclusion, we present a new role of hnRNPA1 in promoting Treg function, indicating it as a promising target for tumor therapies.
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