化学选择性
电泳剂
羧酸
化学
三氟甲基
基质(水族馆)
组合化学
功能群
有机化学
催化作用
海洋学
地质学
聚合物
烷基
作者
Xanath Ispizua‐Rodriguez,Sócrates B. Munoz,Vinayak Krishnamurti,Thomas Mathew,G. K. Surya Prakash
标识
DOI:10.1002/chem.202102854
摘要
Abstract A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones from widely available carboxylic acids is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chemicals. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late‐stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.
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