清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Concomitant development of neurologic and cardiac immune-related adverse effects in patients treated with immune checkpoint inhibitors for melanoma

医学 易普利姆玛 无容量 心肌炎 不利影响 内科学 相伴的 黑色素瘤 重症肌无力 外科 癌症 免疫疗法 癌症研究
作者
Panagiotis Diamantopoulos,Katerina Tsatsou,Οlga Benopoulou,Μaria Bonou,Amalia Anastasopoulou,Elpida Mastrogianni,Helen Gogas
出处
期刊:Melanoma Research [Lippincott Williams & Wilkins]
卷期号:30 (5): 484-491 被引量:11
标识
DOI:10.1097/cmr.0000000000000681
摘要

Immune checkpoint inhibitors (ICI) have altered the prognosis of patients with melanoma over the past few years, with immune-related adverse effects (irAEs) being the only factor limiting their use. Neurologic and cardiac irAEs are rare, but usually severe. We reviewed the files of patients with melanoma treated with ICIs in one center to retrieve data from patients with neurologic irAEs. Patients with a combination of neurologic and cardiac manifestations were further analyzed. We also reviewed the literature for similar syndromes. Five out of 482 (1.01%) patients developed a neurologic syndrome and we present three patients with a constellation of neurologic and cardiac irAEs. A 66-year-old woman and a 68-year-old man presented with a constellation of findings after being treated with ipilimumab and nivolumab, respectively, for melanoma in the adjuvant setting and were eventually diagnosed with myasthenia gravis with cardiac involvement. An 80-year-old woman developed diffuse asymmetric muscle weakness, bilateral ptosis and asymptomatic high serum troponin levels after adjuvant treatment with nivolumab and ipilimumab for a stage IIIB melanoma. After excluding ischemic heart disease, she was diagnosed with axonal polyradiculoneuropathy and myocarditis. Neurologic or cardiac irAEs in patients treated with ICIs are uncommon (<1%), but usually severe, with high rates of morbidity and fatality. The co-development of neurologic and cardiac irAEs is even more rare and can arise soon after exposure to ICIs and escalate rapidly. Since more and more patients are now treated with ICIs in the adjuvant setting, prompt identification and management are essential to avoid serious complications or death.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
明亮不乐发布了新的文献求助10
5秒前
曾经不言完成签到 ,获得积分10
9秒前
科研通AI5应助贪玩钢铁侠采纳,获得10
11秒前
明亮不乐完成签到,获得积分10
12秒前
15秒前
16秒前
啦啦啦发布了新的文献求助10
20秒前
杪夏二八完成签到 ,获得积分10
23秒前
24秒前
幽默的南珍完成签到 ,获得积分10
25秒前
26秒前
啦啦啦完成签到,获得积分20
27秒前
twk发布了新的文献求助10
29秒前
LZQ发布了新的文献求助10
30秒前
那那发布了新的文献求助10
31秒前
mey310完成签到 ,获得积分10
34秒前
ding应助twk采纳,获得10
36秒前
今天只做一件事应助那那采纳,获得10
40秒前
典雅问寒应助那那采纳,获得10
40秒前
今天只做一件事应助那那采纳,获得10
40秒前
今天只做一件事应助那那采纳,获得10
40秒前
千葉应助那那采纳,获得10
40秒前
今天只做一件事应助那那采纳,获得10
40秒前
达克赛德完成签到 ,获得积分10
41秒前
LZQ完成签到,获得积分0
43秒前
44秒前
火鸟发布了新的文献求助10
48秒前
56秒前
松柏完成签到 ,获得积分10
1分钟前
1分钟前
tyfelix发布了新的文献求助10
1分钟前
Lxx完成签到 ,获得积分10
1分钟前
nicolaslcq完成签到,获得积分10
1分钟前
无辜的行云完成签到 ,获得积分0
1分钟前
x银河里完成签到 ,获得积分10
1分钟前
专一的从波完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
A China diary: Peking 400
Brain and Heart The Triumphs and Struggles of a Pediatric Neurosurgeon 400
Cybersecurity Blueprint – Transitioning to Tech 400
Mixing the elements of mass customisation 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3784835
求助须知:如何正确求助?哪些是违规求助? 3330070
关于积分的说明 10244288
捐赠科研通 3045435
什么是DOI,文献DOI怎么找? 1671691
邀请新用户注册赠送积分活动 800613
科研通“疑难数据库(出版商)”最低求助积分说明 759541