张力素
间充质干细胞
星形胶质增生
医学
鼻腔给药
脊髓损伤
脊髓
PTEN公司
癌症研究
细胞生物学
免疫学
神经科学
病理
中枢神经系统
生物
内科学
信号转导
PI3K/AKT/mTOR通路
精神科
作者
Shengming Guo,Nisim Perets,Oshra Betzer,Shahar Ben-Shaul,Anton Sheinin,Izhak Michaelevski,Rachela Popovtzer,Daniel Offen,Shulamit Levenberg
出处
期刊:ACS Nano
[American Chemical Society]
日期:2019-08-27
卷期号:13 (9): 10015-10028
被引量:257
标识
DOI:10.1021/acsnano.9b01892
摘要
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits, while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that when given intranasally, exosomes derived from mesenchymal stem cells (MSC-Exo) could pass the blood brain barrier and migrate to the injured spinal cord area. Furthermore, MSC-Exo loaded with phosphatase and tensin homolog small interfering RNA (ExoPTEN) could attenuate the expression of PTEN in the injured spinal cord region following intranasal administrations. In addition, the loaded MSC-Exo considerably enhanced axonal growth and neovascularization, while reducing microgliosis and astrogliosis. The intranasal ExoPTEN therapy could also partly improve structural and electrophysiological function and, most importantly, significantly elicited functional recovery in rats with complete SCI. The results imply that intranasal ExoPTEN may be used clinically to promote recovery for SCI individuals.
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