Endometriosis and migraine headache risk: a meta-analysis

There is high prevalence of both migraine and endometriosis; however, the association between both is controversial. This systematic review evaluated the association between endometriosis and the risk of migraine headache. A search was done of the following international electronic bibliographic databases including: PubMed, Web of Science, and Scopus to May 2020. Heterogeneity among studies was determined by Q-test and I² statistic. Publication bias was assessed by Begg's and Egger's tests. The results were reported using the odds ratio (OR) estimate with its 95% confidence interval (CI) using a random-effects model. The search identified 802 articles with 287,174 participants. There was a significant association between endometriosis and the risk of migraine headache (OR = 1.56; 95% CI: 1.21, 1.90). Based on the Newcastle Ottawa Statement Manual (NOS) scale, all studies had high quality. The findings showed that endometriosis was significantly associated with an increased risk of migraine headache. Future research should be focused on measures that could help to reduce the risk of migraine headache among women with endometriosis.