Synthesis of planar chiral isoquinolinone-fused ferrocenes through palladium-catalyzed C-H functionalization reaction

( S, S )-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C–H functionalization of N -ferrocenyl o -bromobenzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee . The products can be transformed into planar chiral ferrocenyl monophosphines. ( S,S )-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C–H functionalization of N -ferrocenyl o -bromobenzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee . The products can be transformed into planar chiral ferrocenyl monophosphines, which demonstrate their preliminary application.