癌症研究
肺癌
生物
肺
病理
细胞
细胞生物学
癌变
医学
作者
Wael Abdo Hassan,Takaaki Ito
出处
期刊:Histology and Histopathology
日期:2020-10-23
卷期号:36 (1): 69-76
摘要
Background. The Notch signaling pathway
has different roles in many human neoplasms, being
either tumor-promoting or anti-proliferative. In addition,
Notch signaling in carcinogenesis can be tissue
dependent. The aim of the current study is to elucidate
the relation between Notch1 protein expression in lung
cancer cells and the following Notch related proteins:
Hes1, c-Myc, Jagged1 and Jagged2.
Methods. Notch1 and its related proteins were
detected in human lung cancer cell lines and in 54
surgically resected different lung carcinoma tissues.
Then, we used small interfering RNA (siRNA)
technology, to down-regulate the expression of Notch1
in H69AR and SBC3 small cell lung carcinoma (SCLC)
cells. Also, we transfected venus Notch1 intracellular
domain (v.NICD) plasmid into human SCLC lines; H69.
Results. The expression of Hes1, c-Myc and Jagged2
is affected by Notch1 in SCLC.
Conclusion. There is a strong association between
the expression of Notch1 protein and the expression of
Hes1, c-Myc and Jagged2 proteins, which could aid in
better understanding tumorigenesis in SCLC.
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