Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder

自闭症谱系障碍 注意缺陷多动障碍 心理学 楔前 神经科学 功能磁共振成像 认知 眶额皮质 听力学 脑岛 神经影像学 前额叶皮质 自闭症 精神科 医学
作者
Steve Lukito,Luke Norman,Christina Carlisi,Joaquim Raduà,Heledd Hart,Emily Simonoff,Katya Rubia
出处
期刊:Psychological Medicine [Cambridge University Press]
卷期号:50 (6): 894-919 被引量:199
标识
DOI:10.1017/s0033291720000574
摘要

Abstract Background People with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have abnormalities in frontal, temporal, parietal and striato-thalamic networks. It is unclear to what extent these abnormalities are distinctive or shared. This comparative meta-analysis aimed to identify the most consistent disorder-differentiating and shared structural and functional abnormalities. Methods Systematic literature search was conducted for whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies of cognitive control comparing people with ASD or ADHD with typically developing controls. Regional gray matter volume (GMV) and fMRI abnormalities during cognitive control were compared in the overall sample and in age-, sex- and IQ-matched subgroups with seed-based d mapping meta-analytic methods. Results Eighty-six independent VBM (1533 ADHD and 1295 controls; 1445 ASD and 1477 controls) and 60 fMRI datasets (1001 ADHD and 1004 controls; 335 ASD and 353 controls) were identified. The VBM meta-analyses revealed ADHD-differentiating decreased ventromedial orbitofrontal ( z = 2.22, p < 0.0001) but ASD-differentiating increased bilateral temporal and right dorsolateral prefrontal GMV ( z s ⩾ 1.64, p s ⩽ 0.002). The fMRI meta-analyses of cognitive control revealed ASD-differentiating medial prefrontal underactivation but overactivation in bilateral ventrolateral prefrontal cortices and precuneus ( z s ⩾ 1.04, p s ⩽ 0.003). During motor response inhibition specifically, ADHD relative to ASD showed right inferior fronto-striatal underactivation ( z s ⩾ 1.14, p s ⩽ 0.003) but shared right anterior insula underactivation. Conclusions People with ADHD and ASD have mostly distinct structural abnormalities, with enlarged fronto-temporal GMV in ASD and reduced orbitofrontal GMV in ADHD; and mostly distinct functional abnormalities, which were more pronounced in ASD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
4秒前
tomf完成签到,获得积分10
5秒前
7秒前
勤奋冰烟完成签到,获得积分10
7秒前
红炉点血完成签到,获得积分10
9秒前
wei完成签到,获得积分10
9秒前
一一完成签到,获得积分10
10秒前
汉堡包应助勤奋冰烟采纳,获得30
13秒前
14秒前
萌酱完成签到,获得积分10
14秒前
天真怜晴完成签到,获得积分10
15秒前
科研通AI5应助cloud采纳,获得10
16秒前
大气的一德完成签到,获得积分20
18秒前
852应助青岚采纳,获得10
19秒前
老婆婆发布了新的文献求助10
21秒前
21秒前
诠释发布了新的文献求助10
21秒前
24秒前
25秒前
小胖饼饼发布了新的文献求助10
25秒前
29秒前
勤奋冰烟发布了新的文献求助30
29秒前
29秒前
31秒前
32秒前
33秒前
36秒前
Akim应助羽墨空空采纳,获得10
36秒前
九九发布了新的文献求助10
39秒前
cloud发布了新的文献求助10
40秒前
40秒前
42秒前
chen应助科研通管家采纳,获得20
44秒前
chen应助科研通管家采纳,获得20
44秒前
44秒前
bkagyin应助科研通管家采纳,获得10
44秒前
chen应助科研通管家采纳,获得10
44秒前
Owen应助科研通管家采纳,获得10
44秒前
44秒前
高分求助中
Mass producing individuality 600
Разработка метода ускоренного контроля качества электрохромных устройств 500
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
A Combined Chronic Toxicity and Carcinogenicity Study of ε-Polylysine in the Rat 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3824330
求助须知:如何正确求助?哪些是违规求助? 3366627
关于积分的说明 10441769
捐赠科研通 3085883
什么是DOI,文献DOI怎么找? 1697631
邀请新用户注册赠送积分活动 816410
科研通“疑难数据库(出版商)”最低求助积分说明 769640