肥胖
基因组
遗传关联
数量性状位点
孟德尔随机化
计算生物学
作者
Lam Opal Huang,Alexander Rauch,Eugenia Mazzaferro,Michael Preuss,Stefania Carobbio,Cigdem Sevim Bayrak,Nathalie Chami,Zhe Wang,Ursula M. Schick,Nancy Yang,Yuval Itan,Antonio Vidal-Puig,Marcel den Hoed,Susanne Mandrup,Tuomas O. Kilpeläinen,Ruth J. F. Loos
标识
DOI:10.1038/s42255-021-00346-2
摘要
Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The mechanisms that uncouple adiposity from its cardiometabolic complications are not fully understood. Here, we identify 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk. Functional analyses show that the 62 loci are enriched for genes expressed in adipose tissue, and for regulatory variants that influence nearby genes that affect adipocyte differentiation. Genes prioritized in each locus support a key role of fat distribution (FAM13A, IRS1 and PPARG) and adipocyte function (ALDH2, CCDC92, DNAH10, ESR1, FAM13A, MTOR, PIK3R1 and VEGFB). Several additional mechanisms are involved as well, such as insulin-glucose signalling (ADCY5, ARAP1, CREBBP, FAM13A, MTOR, PEPD, RAC1 and SH2B3), energy expenditure and fatty acid oxidation (IGF2BP2), browning of white adipose tissue (CSK, VEGFA, VEGFB and SLC22A3) and inflammation (SH2B3, DAGLB and ADCY9). Some of these genes may represent therapeutic targets to reduce cardiometabolic risk linked to excess adiposity.
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