Steroid-resistant sarcoidosis treated with baricitinib

Sarcoidosis is an immune inflammatory disorder characterised by the presence of granulomatous tissue and can involve one or multiple organs. Glucocorticoids are a mainstay of treatment, but in some patients the maintenance steroid dose can be elevated for daily use and usually immunosuppressive medications such as methotrexate or mycophenolate is associated. In the presence of progressive disease anti-tumour necrosis factors (TNFs) have also been used with apparent success although controlled trials are not available.1 The rheumatologist can be the first speciality to evaluate such patients when articular or extra-articular symptoms are initial modes of presentation.2 Janus kinase (JAK) signal transducer and activator of transcription signalling have been shown to be highly expressed in sarcoid tissue and maybe responsible …