Recent Advances in the Norbornene Mediated Palladium-Catalyzed Domino-Type Catellani Reaction

Catellani reaction is a kind of domino reaction that can achieve direct functionalization of the unactivated remote aromatic C-H bond, based on the use of a palladium catalyst and norbornene.Through the selective activation of the C-H bond which located at the ortho position of C-X, and a subsequent direct cross coupling reaction in the ipso position of aryl halide, the reaction employing aryl halide as a starting material opens a way for the selective formation of many new chemical bonds, as well as multi-substituted aromatic or aza-heterocyclic derivatives in a single reaction vessel.The recent advancements that introducing different strategies to terminate the typical Catellani reaction are mainly summarized.