斑马鱼
达尼奥
生物
模式生物
疾病
计算生物学
遗传学
病理
医学
基因
作者
Jill M. Keller,Evan T. Keller
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2018-01-01
卷期号:: 351-359
被引量:8
标识
DOI:10.1016/b978-0-12-811353-0.00026-9
摘要
Zebrafish (Danio rerio) have been extensively utilized for understanding mechanisms of development. These studies have led to a wealth of resources including genetic tools, informational databases, and husbandry methods. In spite of all these resources, zebrafish have been underutilized for exploring pathophysiology of disease and the aging process. Zebrafish offer several advantages over mammalian models for these studies, including the ability to perform saturation mutagenesis and the capability to contain thousands of animals in a small space. In this review, we will discuss the use of mature zebrafish as an animal model. The challenges of developing and maintaining a colony of aging zebrafish will be addressed. Specific examples to support the use of mature zebrafish as an animal model will be provided including the demonstration of clinical pathology and that age-associated changes in various phenotypes can be observed in aging zebrafish.
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