空肠
粘蛋白2
断奶
生物
内分泌学
内科学
粘蛋白
免疫印迹
后代
小肠
胎儿
信使核糖核酸
基因表达
男科
怀孕
医学
生物化学
基因
遗传学
作者
Haruka Adachi,Mifuyu Kudo,Shiori Ishiyama,Kazuki Mochizuki
出处
期刊:Nutrition
[Elsevier]
日期:2022-06-01
卷期号:98: 111605-111605
被引量:1
标识
DOI:10.1016/j.nut.2022.111605
摘要
Several recent studies have suggested that malnutrition during developmental periods affects organ function, including that of the small intestine, after birth. However, it is unclear whether carbohydrate or protein restriction during pregnancy affects the expression of mucins and cytokines within the small intestine of offspring.We examined mRNA and protein expression of cytokines and a Muc2 by quantitative reverse transcription polymerase chain reaction and Western blot, respectively, in the jejunoileum of 28- and 46-d-old mice born from mothers fed a low-carbohydrate (LC) or low-protein (LP) diet compared with those born from mothers fed a control diet during pregnancy.The mRNA and protein expressions of Il1b and Il13 in the jejunum in 28-d-old mice were higher in the LP group. Il1b mRNA expression in the jejunum in 46-d-old mice was higher in the LC and LP groups than in controls. The protein levels of mucin 2 in 46-d-old mice were lower in the LP group than in the control group.Fetal protein restriction in mice disrupts jejunal immune- and barrier function-related expression after weaning.
科研通智能强力驱动
Strongly Powered by AbleSci AI