癌症研究
骨溶解
纳米笼
骨转移
肿瘤微环境
破骨细胞
光热治疗
材料科学
癌细胞
乳腺癌
纳米医学
转移
化学
生物物理学
癌症
纳米技术
医学
内科学
肿瘤细胞
生物化学
体外
纳米颗粒
生物
外科
催化作用
作者
Binhua Zou,Zushuang Xiong,Lizhen He,Tianfeng Chen
出处
期刊:Biomaterials
[Elsevier]
日期:2022-06-01
卷期号:285: 121549-121549
被引量:38
标识
DOI:10.1016/j.biomaterials.2022.121549
摘要
Bone metastasis is the major cause of cancer-related morbidity and mortality. To avoid further osteolysis, current treatment ideas focus on tumor cell and the inhibition of osteoclast. Herein, zeolitic imidazolate framework-8-capped Cu2-XSe composite nanoplatform (ICG@Cu2-XSe-ZIF-8) is developed for chemodynamic therapy (CDT) and photothermal therapy (PTT) treatment of malignant breast cancer bone tumors. The rational design of ZIF-8 encapsulation greatly reduces the accumulation of Cu2-XSe to damage the normal cells. Under acidic microenvironment in tumor, ZIF-8 is cleaved to release Cu2-XSe, which can subsequently degrade into Cu (+) and Cu (2+) ions to initiate a Fenton-like reaction inducing CDT. Meanwhile, Cu2-XSe is used to be an effective photothermal transduction agent for exerting the PTT effect. What's more, the selenium element in Cu2-XSe can regulates selenoprotein to inhibit tumor cells and osteoclasts. Of note, the hyperthermia induced by PTT can further enhance the CDT effect in tumor, achieving a synergistic PTT/CDT effect. Based on these advantages, ICG@Cu2-XSe-ZIF-8 effectively suppresses the tumor cells in bone tissue, and reduces the erosion of bone tissue via suppressing osteoclastogenesis. In conclusion, this study demonstrates the potential action mechanism of ZIF-8-capped nanomedicine against osteolysis in bone metastasis.
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