神经科学
多巴胺
被盖腹侧区
厌食症
多巴胺能
中脑
血清素
中缝背核
刺激
5-羟色胺能
中缝
神经传递
内分泌学
心理学
内科学
生物
中枢神经系统
医学
受体
作者
Xiaoyin Cai,Hailan Liu,Bing Feng,Meng Yu,Yang He,Hesong Liu,Changhong Liang,Yongjie Yang,Longlong Tu,Nan Zhang,Lina Wang,Na Yin,Junying Han,Zili Yan,Chunmei Wang,Pingwen Xu,Qi Wu,Qingchun Tong,Yanlin He,Yong Xu
标识
DOI:10.1038/s41593-022-01062-0
摘要
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HTDRN neurons, which causes constant activation of these neurons and contributes to AN-like behaviors. Finally, we found that systemic administration of a DRD1 antagonist can prevent anorexia and weight loss in ABA. Our results revealed regulation of feeding behavior by stimulation strength-dependent interactions between DA and 5-HT neurons, which may contribute to the pathophysiology of AN.
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