Cationic gold(I)-catalyzed glycosylation with glycosyl S-3-butynyl thiocarbonate donors

A cationic gold(I)-catalyzed O-glycosylation method involving the use of glycosyl S-3-butynyl thiocarbonate donors has been developed. It was found that glycosyl S-3-butynyl thiocarbonates are orthogonal to regular phenyl thioglycoside donors. The utilization of this method was demonstrated in the synthesis of a trisaccharide.