化学
分子内力
氢原子
烷基
酰胺
催化作用
芳基
区域选择性
激进的
小学(天文学)
铜
氢
碳原子
组合化学
药物化学
有机化学
物理
天文
作者
Xi Chen,Qiang Wang,Zhe Zhang,Zhi‐Jie Niu,Wei‐Yu Shi,Xiao-Ping Gong,Rui-Qiang Jiao,Minghui Gao,Xue-Yuan Liu,Yong‐Min Liang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-06-10
卷期号:24 (24): 4338-4343
被引量:5
标识
DOI:10.1021/acs.orglett.2c01427
摘要
Herein, we describe the copper-catalyzed arylalkylation of activated alkenes via hydrogen-atom transfer and aryl migration strategy. The reaction was carried out through a radical-mediated continuous migration pathway using N-fluorosulfonamides as the alkyl source. The primary, secondary, and tertiary alkyl radicals formed by intramolecular hydrogen-atom transfer proceeded smoothly. This methodology is an efficient approach for the synthesis of various amide derivatives possessing a quaternary carbon center with good yields and high regioselectivity.
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