肿瘤微环境
免疫系统
免疫疗法
癌症研究
黑色素瘤
癌症免疫疗法
效应器
淋巴结
T细胞
淋巴
癌症
免疫
生物
化学
医学
免疫学
病理
遗传学
作者
Jialu Xu,Qingle Ma,Yue Zhang,Ziying Fei,Yifei Sun,Qin Fan,Bo Liu,Jinyu Bai,Yue Yu,Jianhong Chu,Jingrun Chen,Chao Wang
标识
DOI:10.1038/s41467-021-27750-2
摘要
Microbe-based cancer immunotherapy has recently emerged as a hot topic for cancer treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction of anticancer immunity of our formulations appears to inversely correlate with their size due to the ability to accumulate in tumor-draining lymph node (TDLN). Moreover, we use a percolation model to explain their distribution behavior toward TDLN. The abundance and functional orientation of each effector component are significantly improved not only in the microenvironment in tumor but also in the TDLN following small size YCW NPs treatment. In combination with programmed death-ligand 1 (PD-L1) blockade, we demonstrate anticancer efficiency in melanoma-challenged mice. We delineate potential strategy to target immunosuppressive microenvironment by microbe-based nanoparticles and highlight the role of size effect in microbe-based immune therapeutics.
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