医学
任天堂
硬皮病(真菌)
间质性肺病
疾病
重症监护医学
临床试验
随机对照试验
病因学
托珠单抗
生物信息学
免疫学
病理
内科学
肺
特发性肺纤维化
接种
生物
作者
Heather Bukiri,Elizabeth R. Volkmann
标识
DOI:10.1016/j.coph.2022.102211
摘要
Systemic sclerosis (SSc) is a rare, systemic autoimmune disease of unknown etiology. Among the systemic rheumatic diseases, SSc carries the highest mortality, in part due to the historical lack of disease modifying therapies. Recently, landmark randomized controlled trials (RCTs) have been conducted that have illustrated the heterogeneous nature of SSc and furthered our understanding of the key inflammatory and fibrotic pathways involved in SSc pathogenesis. Although SSc affects various organ systems, RCTs have focused on investigating treatments for diffuse cutaneous sclerosis (dcSSc) and interstitial lung disease (ILD). While recent RCTs for dcSSc have failed to demonstrate a treatment benefit, the outcomes of two RCTs led to the approval of two novel therapies for SSc-ILD: nintedanib and tocilizumab. This review summarizes the salient outcome data from recent SSc trials within a practical clinical framework and points out gaps in knowledge that may help inform the design of future SSc studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI